Gilternib 40mg Tablet (Gilteritinib) – Long Product Description

Gilternib 40mg Tablet (Gilteritinib) is a prescription targeted anti-cancer medicine manufactured by Everest Pharmaceuticals Ltd. It contains Gilteritinib 40mg, a highly effective FLT3 (FMS-like tyrosine kinase 3) inhibitor used for the treatment of relapsed or refractory acute myeloid leukemia (AML) in adult patients with a confirmed FLT3 mutation. By specifically targeting the abnormal FLT3 protein responsible for the uncontrolled growth of leukemia cells, Gilternib helps slow disease progression, promotes cancer cell death, and improves treatment outcomes in eligible patients.

Each pack of Gilternib 40mg Tablet contains 90 tablets, providing a convenient supply for continuous treatment as prescribed by an oncologist. The medicine should only be used after a confirmed FLT3 mutation test, as it is specifically designed for patients whose leukemia carries this genetic mutation.

How Gilternib 40mg Tablet Works

Gilternib contains Gilteritinib, a selective FLT3 tyrosine kinase inhibitor. In many patients with acute myeloid leukemia, mutations in the FLT3 gene cause leukemia cells to multiply rapidly and resist normal cell death. Gilteritinib blocks the activity of the mutated FLT3 protein and related signaling pathways, preventing leukemia cell growth while triggering apoptosis (programmed cell death).

Because it directly targets the underlying genetic mutation, Gilternib offers a more personalized and effective treatment option than conventional chemotherapy for eligible AML patients.

Uses of Gilternib 40mg Tablet

Gilternib 40mg Tablet is indicated for:

• Treatment of relapsed acute myeloid leukemia (AML) with a confirmed FLT3 mutation.
• Treatment of refractory AML in adult patients.
• Targeted therapy following molecular confirmation of FLT3-positive leukemia.
• Long-term management of eligible AML patients under specialist supervision.

A validated FLT3 mutation test should always be performed before initiating treatment.

Benefits of Gilternib 40mg Tablet

Gilternib offers several important clinical benefits, including:

• Specifically targets FLT3-mutated leukemia cells.
• Helps slow the progression of acute myeloid leukemia.
• May improve overall survival in eligible patients.
• Convenient once-daily oral tablet formulation.
• Personalized targeted therapy based on genetic testing.
• May reduce the need for intensive chemotherapy in selected patients.
• Manufactured by Everest Pharmaceuticals Ltd., a trusted pharmaceutical company.

Dosage and Administration

Gilternib 40mg Tablet should be taken exactly as prescribed by an oncologist or hematologist. The usual recommended dose is taken once daily, with or without food. Tablets should be swallowed whole with water and should not be crushed, chewed, or broken.

Treatment continues until disease progression or unacceptable side effects occur. During therapy, patients require regular monitoring through blood tests, liver function tests, electrolyte assessments, and electrocardiograms (ECGs) to ensure treatment safety and effectiveness.

Possible Side Effects

Like other targeted cancer therapies, Gilternib may cause side effects.

Common side effects include:

• Fatigue
• Fever
• Nausea
• Vomiting
• Diarrhea
• Constipation
• Muscle and joint pain
• Elevated liver enzymes
• Swelling of the hands or feet
• Cough
• Shortness of breath

Serious side effects may include:

• Differentiation syndrome
• QT interval prolongation (abnormal heart rhythm)
• Pancreatitis
• Serious liver injury
• Severe infections
• Posterior reversible encephalopathy syndrome (PRES)
• Allergic reactions

Patients should immediately contact their healthcare provider if they experience chest pain, severe shortness of breath, rapid weight gain, persistent fever, seizures, confusion, or severe abdominal pain.

Precautions and Warnings

Before using Gilternib 40mg Tablet, inform your doctor if you have:

• Heart disease or irregular heartbeat
• Liver disease
• Kidney disease
• Pancreatitis
• Electrolyte abnormalities
• Active infections
• Pregnancy or plans to become pregnant

Women and men should use effective contraception during treatment and for the recommended period after the final dose. Breastfeeding is not recommended during therapy.

Storage Information

Store Gilternib 40mg Tablets at room temperature below 30°C, away from heat, moisture, and direct sunlight. Keep the tablets in their original packaging and out of the reach of children.

Why Buy Gilternib 40mg Tablet from MedicineWalyDost?

At MedicineWalyDost, we provide genuine oncology medicines sourced from trusted pharmaceutical manufacturers. Gilternib 40mg Tablet by Everest Pharmaceuticals is available with reliable nationwide delivery across Pakistan for hospitals, oncology clinics, and individual patients requiring specialized leukemia treatment.

When you order from MedicineWalyDost, you receive:

• Genuine oncology medicines
• Competitive prices
• Nationwide delivery across Pakistan
• Secure packaging
• Professional customer support
• Assistance with medicine availability and ordering

Note: A valid prescription from a qualified oncologist or hematologist is required before purchasing Gilternib 40mg Tablet.

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Frequently Asked Questions (FAQs)

What is Gilternib 40mg Tablet used for?

Gilternib 40mg Tablet is used to treat relapsed or refractory acute myeloid leukemia (AML) in adults with a confirmed FLT3 mutation.

Who manufactures Gilternib 40mg Tablet?

Gilternib 40mg Tablet is manufactured by Everest Pharmaceuticals Ltd.

What is the pack size of Gilternib 40mg Tablet?

Each pack contains 90 tablets.

Is FLT3 mutation testing necessary?

Yes. A confirmed FLT3 mutation test is required before starting treatment because Gilteritinib specifically targets FLT3-mutated leukemia cells.

Is a prescription required?

Yes. Gilternib 40mg Tablet is a prescription-only targeted oncology medicine and should only be used under the supervision of a qualified oncologist.