Ponaxen 15mg Tablets (Ponatinib) – Detailed Product Description

What is Ponaxen 15mg (Ponatinib)?

Ponaxen 15mg is a prescription medication containing Ponatinib Hydrochloride, a third-generation tyrosine kinase inhibitor (TKI) used in the treatment of chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). It is particularly beneficial for patients who have developed resistance to earlier generation TKIs or have the T315I mutation, which makes other treatments ineffective.

Key Benefits of Ponaxen 15mg

Ponaxen targets and inhibits the abnormal BCR-ABL tyrosine kinase produced by the Philadelphia chromosome mutation. It is especially effective against mutation-resistant forms of leukemia, offering a significant treatment option for patients who have failed prior therapies. This makes it a crucial choice in the management of advanced or resistant blood cancers.

Medical Uses of Ponaxen in Pakistan and Globally

Ponaxen 15mg is used for:

• Treatment of chronic phase, accelerated phase, or blast phase CML in adults resistant or intolerant to previous TKI therapy.

• Treatment of Ph+ ALL, especially in patients who have failed prior treatment.

• Also considered in newly diagnosed Ph+ ALL in combination with chemotherapy under specialist supervision.

In Pakistan, Ponaxen is prescribed by oncologists and hematologists for cases where standard therapies have failed or mutations like T315I are detected.

Pack Size

(30 Tablet)

Manufacturer:

Everest Pharmaceutical Ltd

Dosage and Administration

• Initial adult dose: 45mg once daily with or without food.

• Dose adjustment: Upon achieving major response, dose is often reduced to 15mg daily to minimize side effects.

• Pediatric use: Not typically recommended unless specified by a specialist.

• Liver impairment: May require a lower starting dose (e.g., 30mg daily).

• Tablets should be swallowed whole with water. Avoid crushing or breaking the tablet.

Never self-adjust the dose. Always follow your oncologist’s recommendation based on blood counts, liver tests, and treatment response.

Side Effects of Ponaxen 15mg Tablets

Common Side Effects:

• Nausea, vomiting, and abdominal pain

• Headache, fatigue, dizziness

• Rash, dry skin

• Constipation or diarrhea

• High blood pressure (hypertension)

• Joint pain, muscle aches

• Fever and low blood counts

Serious Side Effects:

• Blood clots or arterial blockages (heart attack, stroke, limb ischemia)

• Heart failure

• Liver toxicity (increased liver enzymes or jaundice)

• Pancreatitis

• Severe bleeding

• Tumor lysis syndrome (rapid breakdown of cancer cells)

• Hypertension crisis

• Vision changes or eye disorders

Always report any unusual symptoms or severe reactions to your doctor immediately.

Precautions Before Using Ponaxen

• Pregnancy and breastfeeding: Ponaxen is not safe. Women of childbearing age must use effective contraception during treatment.

• Heart conditions: Use with caution in patients with a history of heart attack, stroke, or high blood pressure.

• Liver or kidney disease: May require monitoring or dose adjustments.

• Surgery or dental procedures: Inform your doctor or dentist that you’re on Ponatinib due to bleeding risks.

Avoid grapefruit juice, which can increase drug levels and toxicity. Regular monitoring is required, including blood pressure, liver function, and complete blood counts.

Contraindications

Ponaxen should not be used in the following cases:

• Known allergy to Ponatinib or any component of the tablet

• Pregnant or breastfeeding women

• Severe uncontrolled cardiovascular disease

• Active bleeding disorders

Ponaxen 15mg Price in Pakistan

MedicineWalyDost.com is the trusted and leading online pharmacy in Pakistan, offering the best prices for oncology and other imported medicines.

For the most accurate and up-to-date price of Ponaxen 15mg Tablets, contact them directly:

📞 WhatsApp: +92 315 7733383

Whether you’re in Karachi, Lahore, Islamabad, or anywhere across Pakistan, MedicineWalyDost.com ensures genuine medicine with professional support and nationwide delivery.

Storage Instructions

• Store at room temperature (20°C to 25°C)

• Protect from moisture and direct sunlight

• Keep out of reach of children and pets

• Do not use expired medicine

Frequently Asked Questions (FAQs)

1. Is Ponaxen 15mg available in Pakistan without a prescription?

No. Ponaxen is a prescription-only cancer medication and should be used under the supervision of a qualified oncologist or hematologist.

2. Can I use Ponaxen as a first-line treatment?

Usually not. Ponaxen is reserved for patients who are resistant or intolerant to first- and second-generation TKIs. It may be used upfront in specific high-risk mutations like T315I.

3. Can I reduce the dose to 15mg after starting with 45mg?

Yes. Dose reduction is common after achieving a major molecular or cytogenetic response to reduce the risk of side effects, especially vascular complications.

4. Can Ponaxen cure leukemia?

Ponaxen is not a cure but can lead to deep remission or long-term disease control in CML and Ph+ ALL. Some patients remain stable for years on treatment.

5. Is financial support available for Ponaxen in Pakistan?

Some NGOs and hospital foundations may offer limited support. Patients are advised to inquire with cancer support organizations or their treating hospital about available programs.

Conclusion

Ponaxen 15mg Tablets (Ponatinib) is a lifesaving treatment option for leukemia patients with resistance to other TKIs. Its powerful mechanism of action makes it especially useful for treating CML and Ph+ ALL with complex mutations like T315I. While effective, it requires strict medical supervision, regular monitoring, and awareness of serious side effects.

For updated pricing, dosage guidance, and availability in Pakistan, contact MedicineWalyDost.com WhatsApp.