Olanib 150mg Tablet (Olaparib) – Complete Product Overview

Olanib 150mg Tablet contains Olaparib, a targeted anti-cancer medicine that belongs to the class of PARP inhibitors. It is specifically designed for the treatment of cancers in patients with BRCA1 or BRCA2 gene mutations. By blocking the PARP enzyme, which repairs damaged DNA in cells, Olanib helps prevent cancer cells from recovering, leading to their death and slowing disease progression.

This medicine is widely recognized for its role in managing advanced ovarian cancer, metastatic breast cancer, pancreatic cancer, and prostate cancer in patients who meet certain genetic and clinical criteria.

Uses of Olanib 150mg Tablet

Olanib is indicated for the treatment of:

• Advanced ovarian cancer: Used as maintenance therapy in patients who have responded to platinum-based chemotherapy.

• Metastatic breast cancer: Especially in HER2-negative patients with BRCA gene mutations.

• Pancreatic cancer: For patients with germline BRCA mutations whose disease is stable after chemotherapy.

• Prostate cancer: In metastatic castration-resistant prostate cancer patients with BRCA mutations who have failed previous treatments.

Its targeted mechanism makes it particularly effective in genetically selected patients, offering better disease control and prolonged remission.

Dosage and Administration

• Standard Dose: 300mg twice daily (two 150mg tablets in the morning and two in the evening).

• Can be taken with or without food but should be swallowed whole with water.

• Missed Dose: If a dose is missed, skip it and take the next scheduled dose—do not double up.

• Renal Impairment: For moderate kidney problems, the dose may be reduced to 200mg twice daily.

• Hepatic Impairment: Mild to moderate cases usually require no adjustment, but severe cases are avoided.

• The treatment continues until there is disease progression or unacceptable toxicity.

How Olanib Works

Olanib blocks the PARP (Poly ADP-Ribose Polymerase) enzyme, which plays a vital role in repairing damaged DNA. Cancer cells with BRCA mutations depend heavily on PARP for survival. By inhibiting this enzyme, Olanib causes these cancer cells to accumulate DNA damage and eventually die—a process known as synthetic lethality.

Common Side Effects of Olanib 150mg

Like all cancer medicines, Olanib can cause side effects, some of which may be temporary and manageable:

• Nausea

• Fatigue or weakness

• Vomiting

• Diarrhea

• Loss of appetite

• Headache

• Dizziness

• Changes in taste

• Anemia (low red blood cells)

• Low platelet count

• Shortness of breath or cough

Serious Side Effects and Warnings

• Myelodysplastic Syndrome (MDS) / Acute Myeloid Leukemia (AML): Rare but serious blood disorders; requires regular blood monitoring.

• Pneumonitis: Inflammation of the lungs; report new or worsening cough and breathing difficulty immediately.

• Blood Clots: Deep vein thrombosis (DVT) or pulmonary embolism can occur.

• Fetal Toxicity: Can cause harm to unborn babies; avoid use in pregnancy and use effective contraception.

• Breastfeeding: Not recommended during treatment.

Precautions Before Taking Olanib

• Perform a pregnancy test before starting treatment.

• Use reliable contraception during treatment and for several months after.

• Avoid grapefruit or Seville oranges, which can affect drug metabolism.

• Inform your doctor about all other medications or supplements you are taking.

• Have regular complete blood counts (CBC) and liver function tests.

Contraindications

• Known hypersensitivity to Olaparib or any of its ingredients.

• Pregnancy and breastfeeding.

• Severe liver or kidney impairment (unless approved by a specialist).

Price of Olanib 150mg Tablet in Pakistan

Olanib 150mg Tablet is considered a premium oncology medicine, and prices vary by city, supplier, and pack size. In Pakistan, it typically ranges between Rs. 130,000 to Rs. 180,000 per pack. For the most accurate and updated price, consult a reliable pharmacy or cancer care supplier.

Frequently Asked Questions (FAQs)

1. What is Olanib 150mg used for?
It is used to treat BRCA-mutated ovarian, breast, pancreatic, and prostate cancers.

2. How long do I need to take Olanib?
Treatment duration varies and continues until the disease worsens or side effects become intolerable.

3. Can I take Olanib with food?
Yes, it can be taken with or without food, but always swallow tablets whole.

4. Is Olanib safe during pregnancy?
No, it can harm the unborn baby and must not be used during pregnancy.

5. What should I do if I miss a dose?
Skip the missed dose and take the next one as scheduled—never double the dose.

6. Does Olanib cause hair loss?
Hair loss is not common with Olanib, but fatigue, nausea, and low blood counts are more frequent.

Final Thoughts

Olanib 150mg Tablet (Olaparib) is a breakthrough targeted therapy for patients with BRCA-mutated cancers, offering hope where traditional treatments may not be as effective. With proper patient selection, monitoring, and medical supervision, it can extend survival and improve quality of life. While the cost is high, its clinical benefits make it a vital option in modern cancer care.