Niranib 100mg Capsule is a prescription medication containing Niraparib, a potent PARP inhibitor used in the maintenance treatment of adult patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer. Manufactured by Everest Pharmaceuticals Ltd., Niranib offers a targeted approach to cancer therapy by interfering with DNA repair mechanisms in cancer cells, leading to their death.

🩺 Therapeutic Indications

Niranib 100mg is indicated for:

• Maintenance treatment of adult patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in complete or partial response to platinum-based chemotherapy.

⚙️ Mechanism of Action

Niraparib, the active ingredient in Niranib, is a selective inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes. By inhibiting PARP, Niraparib prevents cancer cells, particularly those with BRCA mutations, from repairing their DNA effectively, leading to cell death. This targeted action helps prolong progression-free survival in patients with specific cancer types.

💊 Dosage & Administration

Recommended Dosage:

• The typical starting dose is 300 mg (three 100 mg capsules) taken orally once daily.

Administration Guidelines:

• Niranib can be taken with or without food.
• Swallow capsules whole; do not crush or chew.
• Take the dose at the same time each day.

Dose Adjustments:

• Dose modifications may be necessary based on individual patient tolerability, body weight, platelet count, and the occurrence of adverse reactions.

⚠️ Warnings & Precautions

• Hematologic Toxicity: Regular monitoring of complete blood counts is essential due to risks of thrombocytopenia, anemia, and neutropenia.
• Hypertension: Monitor blood pressure regularly; manage elevated readings promptly.
• Myelodysplastic Syndrome/Acute Myeloid Leukemia: Cases have been reported; monitor patients for new or worsening hematologic abnormalities.
• Embryo-Fetal Toxicity: Niranib can cause fetal harm; advise women of reproductive potential to use effective contraception during treatment and for six months after the last dose.

🚫 Contraindications

• Known hypersensitivity to Niraparib or any component of the formulation.

🤒 Common Side Effects

• Nausea
• Fatigue
• Anemia
• Thrombocytopenia
• Constipation
• Vomiting
• Abdominal pain
• Insomnia
• Headache
• Hypertension

Patients should report any unusual symptoms to their healthcare provider promptly.

📦 Storage

• Store at room temperature, below 30°C.
• Keep in the original packaging to protect from moisture.
• Keep out of reach of children.

🏭 Manufacturer

Everest Pharmaceuticals Ltd.

📌 Note

Niranib 100mg Capsule should be used under the supervision of a qualified healthcare professional. Regular monitoring of blood counts and blood pressure is essential during treatment.