Myfortic 360mg Tablet contains mycophenolic acid, an immunosuppressive agent used to prevent organ rejection in patients who have undergone kidney transplantation. It is typically prescribed alongside other immunosuppressants like cyclosporine and corticosteroids to enhance its effectiveness.

Mechanism of Action:
Mycophenolic acid works by inhibiting inosine monophosphate dehydrogenase (IMPDH), an enzyme crucial for the proliferation of T and B lymphocytes. By suppressing these immune cells, Myfortic reduces the likelihood of the body rejecting the transplanted organ.

Dosage and Administration:

• Adults: The recommended dose is 720 mg taken twice daily (totaling 1,440 mg per day).
• Pediatric Patients (≥5 years): Dosage is based on body surface area, with a maximum of 720 mg twice daily.
• Tablets should be swallowed whole without crushing or chewing to maintain their enteric coating.
• Consistency in dosing time is advised, and the medication can be taken with or without food.

Common Side Effects:

• Gastrointestinal issues: nausea, vomiting, diarrhea, abdominal pain.
• Headache.
• High blood pressure.
• Decreased white blood cell count, increasing infection risk.
• Anemia.
• Muscle pain.
• Acne.

Serious Side Effects:

• Increased susceptibility to infections, including bacterial, fungal, and viral.
• Elevated risk of certain cancers, such as lymphoma and skin cancer.
• Potential for progressive multifocal leukoencephalopathy (PML), a rare but serious brain infection.
• Signs of severe allergic reactions: rash, itching, swelling, dizziness, difficulty breathing.

Precautions:

• Pregnancy: Myfortic is contraindicated due to the risk of birth defects and miscarriage.
• Breastfeeding: Not recommended, as the drug may pass into breast milk.
• Sun Exposure: Patients should minimize sun exposure and use protective measures due to increased skin cancer risk.
• Regular monitoring of blood counts and kidney function is essential during treatment.

Storage:

• Store at room temperature, away from moisture and heat.
• Keep out of reach of children.

Manufacturer:

• Brand Name: Myfortic
• Manufacturer: Novartis
• Packaging: Available in 360 mg delayed-release tablets.