Lorbrexen 100mg Tablet (Lorlatinib) – Complete Guide 

Lorbrexen 100mg Tablet contains Lorlatinib, a third-generation ALK- and ROS1-positive non–small cell lung cancer (NSCLC) targeted therapy. As an oral tyrosine kinase inhibitor (TKI), Lorbrexen dramatically improves outcomes in patients with ALK-positive advanced lung cancer, especially those resistant to earlier ALK inhibitors.

Lorbrexen 100mg Tablet Uses

• Designed to treat ALK-positive metastatic non–small cell lung cancer, especially in patients who have already received at least one prior ALK TKI therapy.

• Effective in overcoming resistance mutations, such as ALK G1202R.

• Helps penetrate the blood-brain barrier, making it effective against ALK-positive brain metastases.

• Enables home-based oral lung cancer treatment, reducing hospital visits and improving quality of life.

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Manufacturer & Pack Size in Pakistan

• Brand Name: Lorbrexen 100 mg Tablet

• Generic Name: Lorlatinib (oral)

• Manufacturer: Everest Pharmaceuticals Ltd., A licensed pharmaceutical manufacturer recognized for oncology-grade medications in Bangladesh.

• Pack Sizes Available: 30 tablets per pack (sufficient for a 30-day treatment cycle)

Always verify pack size with your oncologist before ordering to align with your treatment schedule.

Dosage & Administration Guidelines

• Standard Adult Dose: 100 mg once daily, taken orally with or without food.

• Take at around the same time each day.

• Swallow the tablet whole—do not crush, chew, or dissolve.

• Dose reduction options include 75 mg or 50 mg daily for managing side effects.

• Regular monitoring of liver function, blood lipids, and mental health is essential to adjust dosing.

Common & Serious Side Effects

Common Side Effects:

• High cholesterol (hyperlipidemia)

• Peripheral edema (swelling)

• Fatigue, neuropathy (numbness or tingling)

• Nausea, diarrhea, constipation

• Weight gain

• Mood changes, cognitive impairment

Serious Side Effects:

• Severe cognitive or mood changes such as depression, hallucinations

• Liver toxicity – elevated liver enzymes

• Hyperglycemia (high blood sugar)

• Pulmonary effects (rare but include pneumonitis)

• Cardiac arrhythmias or QT prolongation

Patients should undergo monthly liver and lipid panels, as well as neurological evaluations, especially during the initial treatment phase.

Important Precautions

• Lipid monitoring: Manage cholesterol levels proactively with medication if needed.

• Mental health: Report mood changes, memory problems, or hallucinations immediately.

• Liver health: Regular liver tests are essential—stop treatment if transaminases reach 3x the upper limit or bilirubin increases.

• Drug interactions: Avoid strong CYP3A4 inducers (e.g., rifampin) and inhibitors (e.g., ketoconazole).

• Sun exposure: Wear sun protection—photosensitivity reactions may occur.

Contraindications

• Known hypersensitivity to Lorlatinib or any component of Lorbrexen.

• Pregnant or breastfeeding women—contraindicated due to potential harm.

• Severe hepatic impairment (Child–Pugh C)—use only under specialist supervision.

• Uncontrolled psychiatric or neurological disorders.

Discuss your full medical history — including liver health, mental health, and other medications — with your oncologist to ensure Lorbrexen is suitable for you.

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Storage Instructions

• Store room temperature (20–25 °C) in original packaging.

• Shield from heat, moisture, and direct sunlight.

• Keep out of reach of children and pets.

• Dispose of expired or unused tablets following local guidelines.

Frequently Asked Questions (FAQs)

1. How long will my treatment with Lorbrexen last?

Treatment generally continues until disease progression or intolerable side effects. Many patients remain on Lorlatinib therapy for several months with ongoing monitoring.

2. If I miss a dose, what should I do?

Take it promptly if remembered on the same day. If it’s close to your next dose, skip the missed one. NEVER double-dose. Inform your oncologist if multiple doses are missed.

3. Can Lorbrexen cross into the brain?

Yes, its ability to cross the blood-brain barrier makes it particularly effective for treating ALK-positive brain metastases.

4. Will Lorbrexen cure my cancer?

Lorbrexen is not a cure but can significantly delay disease progression, improve symptoms, and extend survival in ALK-positive NSCLC patients.

5. Is cost a barrier in Pakistan?

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