Keytruda 100 mg Injection (Pembrolizumab) – Complete Product Guide

Keytruda 100 mg Injection, containing the active drug Pembrolizumab, is a widely respected immunotherapy used across numerous advanced cancers. As a PD-1 immune checkpoint inhibitor, it enables the immune system to recognize and attack cancer cells more effectively. In Pakistan, Keytruda is a critical component in modern oncology, combining promising results with manageable administration protocols.

Uses of Keytruda 100 mg Injection

This immuno-oncology injection is prescribed for several cancer types, including:

• Non-small cell lung cancer (NSCLC) – used as monotherapy or in combination with chemotherapy

• Melanoma – in both metastatic and adjuvant settings

• Head and neck cancers – effective in recurrent or metastatic cases

• Classical Hodgkin lymphoma in relapsed or refractory situations

• Urothelial carcinoma – for advanced or metastatic bladder cancer

• Cervical cancer, esophageal cancer, gastric cancer, and endometrial cancer – particularly in patients with specific genetic markers (like MSI-H or PD-L1 expression)

• Tissue-agnostic use – for tumors with mismatch repair deficiency across different cancer types

Keytruda’s broad spectrum makes it a vital treatment in personalized cancer care, especially where traditional therapies fall short.

How Keytruda Works

Pembrolizumab blocks the PD-1 pathway, which cancer cells exploit to evade immune detection. By inhibiting this checkpoint, Keytruda reactivates T-cells, allowing them to identify and destroy cancer cells. This immunostimulatory action can result in long-lasting cancer remission in responsive patients.

Dosage and Administration

Standard Dosing

• Adult dose: Typically 200 mg every 3 weeks, or 400 mg every 6 weeks depending on treatment plan and cancer type.

• Formulation: Packaged in 100 mg vials for IV infusion.

• Administration: Given via intravenous infusion over at least 30 minutes in a hospital or infusion center.

Handling & Missed Doses

• Must be prepared by healthcare professionals under controlled conditions.

• If a dose is missed, it should be rescheduled promptly—your oncologist will guide adjustments.

• Treatment duration varies; it may continue until disease progression or unacceptable toxicity.

Common Side Effects of Keytruda

While many patients tolerate Keytruda well, common side effects can include:

• Fatigue, nausea, diarrhea, loss of appetite

• Skin rash or itching

• Cough, shortness of breath, mild fever

• Muscle or joint pain

• Headache

These are usually mild to moderate and manageable with supportive care.

Serious Side Effects and Immune-Related Risks

Pembrolizumab can cause immune-mediated effects that require immediate attention:

• Pneumonitis – respiratory symptoms like persistent cough or breathlessness

• Colitis – abdominal pain or severe diarrhea

• Hepatitis – things like yellowing of eyes or dark urine

• Endocrine issues – thyroid dysfunction, adrenal insufficiency, or new-onset diabetes

• Nephritis – signs such as reduced urine output or swelling

• Severe infusion reactions – fever, difficulty breathing, or low blood pressure during administration

Timely medical intervention can often resolve these complications.

Precautions Before Starting Keytruda Injection

• Conduct baseline screening (liver, kidney, thyroid function; blood counts; hormone levels)

• Evaluate for history of autoimmune conditions or organ transplant

• Advise women of childbearing age to use effective contraception during and for at least 4 months after therapy; avoid during pregnancy and breastfeeding

• Avoid live vaccines during treatment and up to at least 4 months afterward

• Inform your oncologist of all medications and supplements to rule out interactions

Contraindications

Keytruda should not be used if:

• You have a known allergy to Pembrolizumab or any component

• You are pregnant or breastfeeding

• You have uncontrolled autoimmune disease or recent organ transplant failure

• You are receiving live vaccines during treatment

Keytruda 100 mg Injection Price in Pakistan

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Frequently Asked Questions (FAQs)

Q1: Which cancers are treated with Keytruda?
Keytruda treats NSCLC, melanoma, head and neck cancer, Hodgkin lymphoma, bladder cancer, and certain stomach, cervical, esophageal, and endometrial cancers with specific genetic biomarkers.

Q2: How is Keytruda administered?
It is administered as an intravenous infusion every 3 or 6 weeks in a medical setting.

Q3: Can it be used during pregnancy?
No. It is not recommended during pregnancy, and women should use contraception during and after treatment.

Q4: What major side effects should I report?
Serious symptoms like trouble breathing, severe diarrhea, persistent cough, jaundice, or sudden fatigue must be reported immediately.

Q5: Where can I buy genuine Keytruda in Pakistan?
Reliable cancer pharmacies or hospital dispensaries are the best source. Always verify authenticity and availability.

Final Summary

Keytruda 100 mg Injection (Pembrolizumab) is a breakthrough immunotherapy for several advanced cancers. It empowers the immune system to target cancer more effectively and may result in long-term benefits for responsive patients. While generally safe, regular monitoring and quick response to side effects are essential. Available in Pakistan with a premium price tag, Keytruda should be obtained through authorized medical channels and administered under oncologist supervision for optimal outcomes.