Avastin 400mg Injection (Bevacizumab) – Complete Product Description

Avastin 400mg Injection (Bevacizumab) is a prescription anti-cancer medicine manufactured by Roche. It contains bevacizumab, a recombinant monoclonal antibody that belongs to the class of medicines known as angiogenesis inhibitors. Avastin works by targeting vascular endothelial growth factor (VEGF), a protein that helps tumors develop new blood vessels.

By blocking VEGF, Avastin can help reduce the formation of new blood vessels that tumors need for growth and survival. It is used as part of specific treatment regimens for several types of cancer, depending on the patient’s diagnosis, disease stage, previous treatment and applicable treatment guidelines.

Avastin 400mg is supplied as a concentrate for intravenous infusion. The product listed here has a pack size of 1 injection, making it an important specialized oncology medicine for use under the supervision of a qualified healthcare professional.

Avastin 400mg Injection – Product Information

Brand Name: Avastin
Active Ingredient: Bevacizumab
Strength: 400mg
Dosage Form: Concentrate for solution for intravenous infusion
Route of Administration: Intravenous (IV) infusion
Manufacturer: Roche
Pack Size: 1 injection
Drug Class: Anti-VEGF monoclonal antibody
Therapeutic Class: Antineoplastic / targeted cancer therapy
Prescription Status: Prescription medicine

Avastin is a specialized biological medicine. It should be prepared and administered by appropriately trained healthcare professionals and should not be self-injected.

What Is Avastin 400mg Injection Used For?

Avastin (Bevacizumab) is used in combination with other anticancer medicines for the treatment of selected cancers. Its approved uses can vary according to the country and regulatory authority.

Depending on the treatment indication, bevacizumab may be used for certain patients with:

• Metastatic colorectal cancer
• Non-small cell lung cancer
• Glioblastoma
• Metastatic renal cell carcinoma
• Cervical cancer
• Ovarian, fallopian tube or primary peritoneal cancer
• Certain other approved cancer indications

The choice of Avastin depends on the patient’s cancer type, stage, previous treatment, overall health and the specific treatment protocol recommended by the oncologist.

Avastin for Colorectal Cancer

Bevacizumab may be used with chemotherapy for selected patients with metastatic colorectal cancer. It works by inhibiting VEGF-mediated blood-vessel formation and can be incorporated into specific chemotherapy regimens.

Avastin for Non-Small Cell Lung Cancer

Avastin may be used with certain chemotherapy combinations for appropriately selected patients with non-squamous non-small cell lung cancer (NSCLC).

The treating oncologist determines whether bevacizumab is suitable based on the patient’s cancer characteristics and medical history.

Avastin for Renal Cell Carcinoma

Bevacizumab can be used in selected patients with metastatic renal cell carcinoma, generally in combination with an appropriate systemic treatment.

Avastin for Gynecological Cancers

Depending on the indication and applicable approval, bevacizumab may be incorporated into treatment regimens for certain ovarian, cervical, fallopian tube and primary peritoneal cancers.

Avastin for Glioblastoma

Bevacizumab may also be prescribed for certain patients with glioblastoma, particularly in specific treatment settings determined by the treating specialist.

How Does Avastin (Bevacizumab) Work?

Avastin contains bevacizumab, which specifically binds to vascular endothelial growth factor (VEGF).

VEGF plays an important role in angiogenesis, the process through which new blood vessels form. Tumors can stimulate angiogenesis to obtain oxygen and nutrients needed for continued growth.

By binding to VEGF, bevacizumab inhibits VEGF activity and can reduce the formation of new blood vessels. This anti-angiogenic effect can help restrict the tumor’s blood supply and is one of the mechanisms through which bevacizumab contributes to cancer treatment.

Avastin is therefore considered a targeted biological cancer therapy rather than traditional cytotoxic chemotherapy.

Avastin 400mg Dose and Administration

Avastin 400mg is administered by intravenous infusion. It must be diluted and administered by a healthcare professional experienced in the use of anticancer medicines.

The correct dose is not the same for every patient. Bevacizumab dosing is generally determined according to the cancer being treated, the treatment regimen, body weight and the patient’s medical condition.

Treatment may be administered at intervals such as every 2 or 3 weeks, depending on the approved indication and combination regimen.

The treating oncologist will determine:

• Appropriate dose
• Infusion schedule
• Duration of treatment
• Other medicines to be given with Avastin
• Whether treatment should be delayed, reduced or discontinued

Do not self-administer Avastin 400mg Injection.

Common Side Effects of Avastin 400mg

Like other medicines, Avastin can cause side effects. Some reactions may occur because of its effects on blood vessels and wound healing.

Commonly reported side effects may include:

• High blood pressure
• Weakness or fatigue
• Headache
• Nosebleeds
• Diarrhea
• Loss of appetite
• Abdominal discomfort
• Nausea
• Joint pain
• Muscle pain
• Protein in the urine
• Infusion-related reactions

Not every patient experiences these effects, and their severity can vary.

Serious Side Effects and Risks

Bevacizumab can cause serious or potentially life-threatening adverse reactions. Patients receiving Avastin require appropriate medical monitoring.

Important risks include:

High Blood Pressure

Avastin may cause or worsen hypertension. Blood pressure should be monitored regularly during treatment.

Bleeding

Bevacizumab can increase the risk of bleeding. Patients should report unusual bleeding, coughing up blood, severe nosebleeds or other concerning symptoms.

Gastrointestinal Perforation

A serious but uncommon complication is gastrointestinal perforation. Severe or persistent abdominal pain should receive immediate medical attention.

Wound-Healing Complications

Because VEGF is involved in blood-vessel formation and tissue repair, Avastin may interfere with wound healing. Healthcare professionals may recommend stopping treatment before and after certain surgical procedures.

Blood Clots

Arterial and venous thromboembolic events can occur with bevacizumab treatment. Patients should seek medical attention for symptoms such as chest pain, sudden shortness of breath or sudden weakness.

Kidney Problems

Avastin can cause kidney-related adverse effects, including proteinuria. Urine and kidney function may be monitored during treatment.

Precautions Before Using Avastin

Before receiving Avastin 400mg Injection, tell your healthcare provider if you have:

• High blood pressure
• A history of blood clots
• Bleeding problems
• Recent surgery
• Planned surgery
• Slow-healing wounds
• Gastrointestinal problems
• Kidney disease
• Heart or cardiovascular problems
• Previous reactions to bevacizumab or similar medicines

Inform your doctor about all prescription medicines, over-the-counter medicines, supplements and other cancer treatments you are receiving.

Avastin and Surgery

Special precautions are required around surgical procedures because Avastin can affect wound healing.

Patients should inform their surgeon and oncologist if they have recently undergone surgery or are planning surgery. The timing of Avastin treatment around surgery should be determined by the treating healthcare professionals.

Do not stop or change Avastin treatment without medical advice.

Pregnancy and Breastfeeding

Bevacizumab may cause harm to a developing fetus. Women who are pregnant, planning pregnancy or capable of becoming pregnant should discuss the risks with their healthcare provider before starting treatment.

Appropriate contraception may be recommended during treatment and for a period after the final dose.

Breastfeeding should also be discussed with the treating physician because bevacizumab treatment may require interruption of breastfeeding.

Avastin 400mg Storage

Avastin is a biological medicine requiring appropriate temperature-controlled storage.

The injection should be stored and handled according to the manufacturer’s approved requirements. It should be protected from inappropriate temperatures and should not be frozen or shaken.

Because Avastin is an injectable oncology medicine, preparation, storage and administration should be performed by appropriately trained healthcare professionals or authorized pharmaceutical personnel.

Avastin 400mg Injection Price in Pakistan

The Avastin 400mg Injection price in Pakistan can vary according to supplier, availability, import costs, exchange rates and current market conditions.

For the latest Avastin 400mg price in Pakistan, customers can contact MedicineWalyDost.com to check current availability and pricing.

Prices of specialized oncology medicines can change, so customers are encouraged to confirm the latest price before placing an order.

Why Choose Avastin 400mg Injection?

Avastin contains bevacizumab, a well-established anti-VEGF targeted therapy used in specific cancer treatment protocols.

The Roche-manufactured Avastin 400mg presentation provides a high-strength formulation intended for intravenous administration under professional medical supervision.

Because Avastin is a specialized prescription oncology medicine, treatment should be individualized according to the patient’s cancer diagnosis and the recommendation of an experienced oncologist.

Frequently Asked Questions About Avastin 400mg

What is Avastin 400mg Injection?

Avastin 400mg Injection is a prescription biological medicine containing bevacizumab, an anti-VEGF monoclonal antibody used in the treatment of selected cancers.

What is the generic name of Avastin?

The generic name of Avastin is bevacizumab.

Who manufactures Avastin 400mg Injection?

The manufacturer of the product listed here is Roche.

What is the pack size of Avastin 400mg Injection?

The pack size for this product is 1 injection.

How is Avastin 400mg administered?

Avastin 400mg is administered through intravenous infusion by a qualified healthcare professional. It should not be self-administered.

How often is Avastin given?

The dosing schedule varies according to the type of cancer and the treatment regimen. Some regimens use Avastin every two weeks, while others may use an every-three-week schedule.

Is Avastin chemotherapy?

Avastin is not traditional chemotherapy. It is a targeted biological therapy and monoclonal antibody that inhibits VEGF. It may, however, be used together with chemotherapy.

What cancers can Avastin treat?

Bevacizumab is used in specific treatment regimens for several cancers, including selected colorectal, lung, kidney, brain and gynecological cancers. The exact approved indication depends on the patient’s disease and applicable regulatory guidance.

Can Avastin be purchased without a prescription?

Avastin is a specialized prescription oncology medicine and should only be supplied and administered under appropriate medical supervision.

Order Avastin 400mg Injection in Pakistan

Looking for Avastin 400mg Injection (Bevacizumab) by Roche in Pakistan?

MedicineWalyDost.com provides access to specialized prescription medicines and oncology products. You can contact us to check the latest Avastin 400mg price, availability and ordering information.

Before ordering, confirm the product’s strength, active ingredient, manufacturer, pack size and prescription requirements with your doctor or pharmacist.

Order Avastin 400mg Injection from MedicineWalyDost.com and contact us today for current availability and pricing.

Important Medical Disclaimer

Avastin 400mg Injection is a prescription cancer medicine. This information is provided for educational and product-description purposes only and does not replace professional medical advice. Always use Avastin under the supervision of a qualified oncologist or healthcare professional. Do not change the dose, treatment schedule or duration without medical advice.