Ascimib 40mg Tablet

Buy Ascimib 40mg Tablet (Asciminib), a targeted therapy for Philadelphia chromosome-positive chronic myeloid leukemia. Order Now at MedicineWalyDost.com for Fast Nationwide Delivery and Learn about its uses, dosage, side effects, and more.

Product Brand: Everest Pharmaceuiticals

Product Currency: pkr

Product Price: 26000

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Ascimib 40mg Tablet: Comprehensive Overview

Ascimib 40mg Tablet (Asciminib) is an advanced medication used in the treatment of Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) in chronic phase (CP). It is specifically designed to target the ABL myristoyl pocket, offering a novel mechanism of action distinct from traditional tyrosine kinase inhibitors (TKIs).

Mechanism of Action

Ascimib works by binding to the ABL myristoyl pocket, a unique site within the BCR-ABL1 fusion protein. This binding inhibits the kinase activity of the fusion protein, disrupting the signaling pathways that promote the proliferation of leukemic cells. Unlike other TKIs that target the ATP-binding site, Ascimib’s allosteric inhibition provides efficacy against certain mutations, including the T315I mutation, which is resistant to many other TKIs.

Indications

Ascimib is indicated for the treatment of adult patients with:

• Newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) in chronic phase (CP).
• Ph+ CML in CP previously treated with two or more TKIs.
• Ph+ CML in CP with the T315I mutation.

Dosage and Administration

• Standard Dosage:
  • 80 mg orally once daily or 40 mg orally twice daily at approximately 12-hour intervals.
  • Administered without food; avoid eating for at least 2 hours before and 1 hour after taking the tablet.
• Missed Dose:
  • If a dose is missed by more than 12 hours (once daily regimen) or more than 6 hours (twice daily regimen), skip the missed dose and take the next dose at the regular time.
  • Do not double the dose to make up for a missed one.

Side Effects

Common Side Effects:

• Musculoskeletal pain
• Fatigue
• Headache
• Nausea
• Rash
• Diarrhea

Serious Side Effects:

• Pancreatitis (inflammation of the pancreas)
• Severe bleeding or easy bruising
• Heart rhythm problems (e.g., irregular heartbeat)
• Liver issues (e.g., elevated liver enzymes)
• Low blood cell counts (e.g., anemia, neutropenia, thrombocytopenia)

Patients should undergo regular blood tests to monitor for potential side effects.

Warnings and Precautions

• Pancreatitis: Ascimib may cause inflammation of the pancreas. Seek immediate medical attention if you experience symptoms such as severe stomach pain, nausea, or vomiting.
• Bleeding Risks: Ascimib can increase the risk of bleeding. Inform your doctor if you have a history of bleeding disorders.
• Heart and Liver Function: Monitor for signs of heart rhythm problems and liver issues during treatment.

Pregnancy and Lactation

• Pregnancy: Ascimib may harm an unborn baby. Use effective contraception during treatment and for at least 1 week after the last dose.
• Lactation: It is unknown if ascimib passes into breast milk. Avoid breastfeeding during treatment and for at least 1 week after the last dose.

Storage Instructions

• Store at room temperature, between 20°C to 25°C (68°F to 77°F).
• Keep the medication in its original container, tightly closed, and protect it from moisture.
• Keep out of reach of children.

Frequently Asked Questions (FAQs)

1. What is Ascimib 40mg Tablet used for?

   • Ascimib is used to treat Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase, including cases that are newly diagnosed, previously treated with two or more TKIs, or harboring the T315I mutation.

2. How should I take Ascimib?

   • Take 80 mg orally once daily or 40 mg orally twice daily on an empty stomach, at least 2 hours before or 1 hour after eating. Swallow the tablet whole.

3. What should I do if I miss a dose?

   • If a dose is missed by more than 12 hours (once daily regimen) or more than 6 hours (twice daily regimen), skip it and take the next dose at the regular time. Do not double the dose.

4. Are there any dietary restrictions?

   • Avoid consuming food for at least 2 hours before and 1 hour after taking Ascimib.

5. Can Ascimib be taken with other medications?

   • Inform your doctor of all medications you are taking, as certain drugs may interact with Ascimib.

6. Is Ascimib available in Pakistan?

   • Availability may vary. Consult with local pharmacies or healthcare providers for information on obtaining Ascimib in Pakistan.

Meta Description

Ascimib 40mg Tablet  is a targeted therapy for Philadelphia chromosome-positive chronic myeloid leukemia. Learn about its uses, dosage, side effects, and more.

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