Alpesib 150 mg Tablet (Alpelisib) – Full Product Overview

Alpesib 150 mg Capsule contains Alpelisib, an advanced PI3K inhibitor designed to target the abnormal growth signals in cancers bearing PIK3CA mutations. This targeted therapy is primarily used in combination with hormone therapy to treat specific types of hormone receptor-positive (HR+), HER2-negative advanced or metastatic breast cancer. Its precision action helps delay tumor progression in patients with genetic vulnerabilities.

Alpesib Tablet Uses

• Advanced or metastatic HR-positive, HER2-negative breast cancer in patients with confirmed PIK3CA mutations, especially after endocrine therapy resistance.

• Rarely, it’s also approved for certain PIK3CA-related overgrowth disorders (PROS).

• Works alongside fulvestrant to enhance cancer cell suppression and improve outcomes.

How It Works

Alpelisib selectively inhibits the PI3Kα pathway, which is often overactive in PIK3CA-mutated tumors. Blocking this pathway reduces cancer cell growth and survival mechanisms, especially when combined with endocrine treatments for enhanced anti-tumor activity.

Recommended Dosage and Administration

• Standard Dose: 300 mg once daily (two 150 mg tablets), taken with food at the same time each day.

• Missed Dose: If missed <9 hours before next dose, take it; if >9 hours, skip and resume the next day—do not double the dose.

• Vomiting After Dose: Do not re-dose on the same day; continue with the next scheduled dose.

• Dosage Adjustments: Required for side effects such as high blood sugar, diarrhea, skin rash, or in cases of kidney or liver impairment.

• Tablet Handling: Swallow whole; do not crush or chew. For those who have trouble swallowing, there are alternate preparations to dissolve the tablets in water for oral administration.

Common Side Effects

• High blood sugar (hyperglycemia), sometimes severe

• Gastrointestinal discomfort like diarrhea, nausea, vomiting, and abdominal pain

• Skin issues such as rash, dry skin, stomatitis, and hair thinning or hair loss

• Fatigue, appetite loss, weight loss

• Less common: infections, mouth ulcers, fever

Serious Side Effects to Watch For

• Severe Hyperglycemia or Diabetic Crisis: Monitor blood sugar closely; may need dose interruption and insulin management.

• Skin Reactions: Rare cases of life-threatening rashes like Stevens-Johnson syndrome or erythema multiforme—stop immediately if they occur.

• Lung Inflammation: Pneumonitis or interstitial lung disease—report any respiratory symptoms right away.

• Liver Toxicity and Blood Disorders: Watch for signs of liver problems or low blood counts, and manage promptly.

Pre-Treatment Precautions

• Confirm the presence of a PIK3CA mutation before initiation.

• Diabetic or pre-diabetic patients need baseline and periodic monitoring of blood sugar and HbA1c.

• Avoid using in people with severe hypersensitivity to the drug or with a history of severe skin reactions.

• Use effective contraception during treatment and for at least one week after the last dose; do not breastfeed.

• Inform your doctor about all medications—including OTCs and herbal supplements—as some may interact.

• Avoid grapefruit juice, which can alter how the medicine is metabolized.

Contraindications

• Known allergy to alpelisib or its ingredients.

• Pregnancy and breastfeeding.

• Use in children is not recommended unless under specialist guidance (PROS scenarios).

Price of Alpesib 150 mg Tablet in Pakistan

Alpesib (Alpelisib) is available in Pakistan through trusted online pharmacies like MedicineWalyDost.com. Conatct at MedicineWalyDost.com’s Help Line +92 315 7733383 for the Currunt Prices and Other Inquiries. Prices may vary by supplier and location, always verify with reliable sources or pharmacies before purchase.

Frequently Asked Questions (FAQs)

Q: What type of cancer does Alpesib treat?
A: It treats advanced HR-positive, HER2-negative breast cancer with PIK3CA mutations.

Q: How long will I need to take this medicine?
A: It continues until disease progression or unacceptable side effects occur, as guided by your oncologist.

Q: Can I take it on an empty stomach?
A: No. It must be taken with food for proper absorption.

Q: What should I do if I miss a dose?
A: If less than 9 hours before your next dose, take it; otherwise, skip and stick to your regular schedule.

Q: Why is blood sugar monitoring important?
A: Because high blood sugar is one of the most common and serious side effects, requiring early detection and treatment.

Q: Is this medicine safe during pregnancy?
A: It’s not safe—effective contraception is a must during treatment and for at least one week afterward.

Summary

Alpesib 150 mg Tablet (Alpelisib) is a targeted, oral cancer therapy designed for PIK3CA-mutated, HR-positive, HER2-negative breast cancer. When used with fulvestrant, it helps slow disease progression. While highly effective, it requires strict monitoring for side effects like hyperglycemia, skin reactions, and lung issues. Available in Pakistan at Best price, it’s essential to use under specialist care with routine labs and follow-up.