Alkixen 250mg Capsule – Comprehensive Product Overview

Alkixen 250mg Capsule is a targeted cancer therapy containing Crizotinib, a tyrosine kinase inhibitor. It is primarily used in the treatment of specific types of non-small cell lung cancer (NSCLC) and anaplastic large cell lymphoma (ALCL) that exhibit genetic alterations such as ALK or ROS1 positivity.

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Key Features

• Active Ingredient: Crizotinib
• Strength: 250 mg per capsule
• Form: Oral capsule
• Packaging: Bottle containing 60 capsules

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Mechanism of Action

Crizotinib functions by inhibiting receptor tyrosine kinases, including ALK, ROS1, and MET. These proteins, when abnormally activated, contribute to the growth and spread of cancer cells. By blocking these pathways, Crizotinib effectively slows down or halts tumor progression.

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Indications

Alkixen 250mg Capsule is indicated for:

• ALK-positive NSCLC: For patients with metastatic non-small cell lung cancer exhibiting ALK gene rearrangements.
• ROS1-positive NSCLC: For patients with metastatic NSCLC harboring ROS1 gene rearrangements.
• ALK-positive ALCL: For pediatric patients aged 1 year and older with relapsed or refractory systemic anaplastic large cell lymphoma that is ALK-positive.

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Dosage and Administration

• Recommended Dose: 250 mg taken orally twice daily.
• Administration: Can be taken with or without food. Swallow capsules whole; do not crush or chew.
• Duration: Continue treatment until disease progression or unacceptable toxicity occurs.

Note: Dosage adjustments may be necessary for patients with hepatic impairment or those experiencing adverse reactions.

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Potential Side Effects

Common Side Effects:

• Nausea and vomiting
• Diarrhea or constipation
• Fatigue
• Visual disturbances
• Elevated liver enzymes

Serious Side Effects:

• Interstitial lung disease
• Hepatotoxicity
• QT interval prolongation
• Bradycardia

Patients should undergo regular monitoring, including liver function tests and electrocardiograms, to detect and manage potential adverse effects.

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Precautions

• Pregnancy: Crizotinib may cause fetal harm. Women of childbearing potential should use effective contraception during treatment and for at least 45 days after the final dose. Men with female partners of reproductive potential should use condoms during treatment and for at least 90 days after the final dose.
• Lactation: It is unknown whether Crizotinib is excreted in human milk. Breastfeeding is not recommended during treatment and for a period after the last dose.
• Fertility: Crizotinib may impair fertility in both males and females.
• Drug Interactions: Inform your healthcare provider about all medications you are taking, as Crizotinib may interact with other drugs.

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Storage Instructions

• Store at room temperature (20°C to 25°C).
• Keep the bottle tightly closed to protect from moisture.
• Keep out of reach of children.

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