Pezinib 400mg Tablet (Pazopanib) – Complete Product Description

Product Name: Pezinib 400mg Tablet
Generic Name: Pazopanib
Strength: 400 mg per tablet
Dosage Form: Film-coated Oral Tablet
Manufacturer: Oncology
Therapeutic Class: Tyrosine Kinase Inhibitor (multi-targeted), Anti-Angiogenesis, Cancer Therapy

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What is Pezinib (Pazopanib) and How It Works

Pazopanib is a potent oral anti-cancer agent that works by inhibiting several key growth factor receptors (VEGFR, PDGFR, FGFR, and c-KIT), thereby blocking tumour angiogenesis (blood vessel growth). This reduction in blood supply can slow or shrink tumours, especially in cancers that rely on high vascular growth.

Because of its multi-kinase inhibition, Pezinib is especially useful in types of cancer that are “vascular” or highly dependent on growth signals, such as renal cell carcinoma and soft tissue sarcoma.

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Indications & Uses of Pezinib 400mg Tablet

Pezinib (Pazopanib) is prescribed for:

• Advanced Renal Cell Carcinoma (RCC): For patients with kidney cancer when surgery is not possible or when it has metastasised.

• Soft Tissue Sarcoma (STS): For advanced or metastatic soft tissue sarcomas (excluding some specific types such as GIST).

• Off-label or investigational uses may include certain other solid tumours, as approved by the treating oncologist.

It is not used in gastrointestinal stromal tumours that respond to other therapies, and it must be taken only under oncology supervision.

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Dosage & Administration

Recommended Dose

• The typical dose for adults with appropriate liver function: 800 mg orally once daily (often as two 400 mg tablets), taken on an empty stomach.

• In some cases, particularly where dose reduction is needed (e.g. moderate hepatic impairment), lower daily doses may be used.

How to Take

• Take Pezinib with a full glass of water.

• Do not crush, break, or chew the tablet.

• The tablet should be swallowed whole.

• Empty stomach rule: At least 1 hour before or 2 hours after a meal. Food, especially high-fat meals, can significantly increase the absorption (AUC), raising risk of side effects.

Missed Dose

If you miss a dose and there are more than 12 hours until the next dose, take it as soon as you remember. If less than 12 hours, skip the missed dose. Do not double up.

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Side Effects & Safety Profile

Common Side Effects

You may experience some of the following side effects when using Pezinib 400mg:

• Nausea, vomiting, diarrhea

• Abdominal pain, loss of appetite (anorexia)

• Elevated blood pressure (hypertension)

• Changes in hair color or hair thinning

• Fatigue, weakness

• Skin rash or discoloration

Serious & Less Common Side Effects

These require monitoring and medical attention:

• Hepatotoxicity: Elevated liver enzymes (ALT, AST), bilirubin, risk of liver injury.

• QT interval prolongation (heart rhythm risk)

• Cardiac dysfunction, reduced heart pumping capacity in some cases

• Bleeding events, hemorrhage risk

• Thrombotic events (clots)

• Gastrointestinal perforation or fistula formation

• Hypertension that may become severe

• Hypothyroidism or other thyroid abnormalities

• Proteinuria (protein in urine)

• Risk of severe infection due to lowered resistance

Monitoring & Laboratory Tests

• Liver Function Tests (LFTs): baseline before starting, then frequently during first 1-4 months, then regularly monthly or as advised.

• Blood Pressure: regular monitoring.

• Thyroid function: baseline and periodically.

• Kidney function, electrolytes, proteinuria.

• ECG if any history of QT prolongation or risk factors.

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Contraindications & Precautions

Contraindications

Pezinib should not be used in:

• Patients with known hypersensitivity to Pazopanib or any of its ingredients.

• Patients with severe hepatic impairment (due to risk of fatal hepatotoxicity).

• Those who are pregnant or breastfeeding.

• Patients with conditions that predispose to severe bleeding or poor wound healing should avoid use or only under close supervision.

Precautions

• Use with caution in patients with heart disease, history of QT prolongation, arrhythmias.

• Carefully manage pre-existing hypertension.

• Avoid in patients with recent serious haemorrhage.

• If surgery is planned or wounds are present, Pezinib may impair healing—consult physician.

• Avoid strong CYP3A4 inhibitors or inducers (drug interactions) that may respectively increase or reduce effective drug concentration.

• Avoid grapefruit and similar foods that interfere with liver enzymes.

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Pack Size & Storage Information

• Pack Size: Usually 30 tablets of 400 mg each.

• Storage: Keep in original packaging, at room temperature (approximately 15-30 °C). Protect from moisture, heat, and light.

• Shelf Life: Use before expiry date printed on label.

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Price of Pezinib 400mg Tablet in Pakistan

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Common Drug Interactions

• Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): can increase levels, risk of toxicity.

• CYP3A4 inducers (e.g., rifampin, certain anti-seizure meds): may reduce Pezinib efficacy.

• Gastric acid reducing agents: may affect absorption; avoid with proton pump inhibitors if possible.

• Other medications that prolong QT interval or affect heart rhythm.

Always provide your full medication list to your doctor before starting Pezinib.

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Frequently Asked Questions (FAQs)

Q1: How long do I need to take Pezinib?
A: Treatment usually continues daily until the disease progresses or side effects become unacceptable. Your oncologist will evaluate benefit vs risk regularly.

Q2: Can I take food or meals with Pezinib?
A: No — take Pezinib on an empty stomach. At least 1 hour before or 2 hours after eating to avoid increased absorption and risk of side effects.

Q3: Is Pezinib safe during pregnancy or breastfeeding?
A: No. It can cause serious harm to an unborn baby. Women of childbearing potential need effective contraception, and avoid breastfeeding during and for a period after treatment.

Q4: What if I miss a daily dose?
A: If more than 12 hours before next dose, take as soon as you remember. Otherwise skip it. Do not double the dose.

Q5: How is Pezinib stored?
A: Store tablets in original packaging, at room temperature (15-30 °C), away from moisture, heat, or light.

Q6: What are the most dangerous side effects to watch out for?
A: Look for signs like yellowing of eyes or skin, dark urine, severe abdominal pain (liver problems); chest pain, fainting or irregular heartbeat; severe bleeding; very high blood pressure; severe rash. Report them immediately.

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