Adcitris 50mg Injection (Brentuximab Vedotin, Imported)

Overview

Adcitris is an advanced antibody-drug conjugate (ADC) designed for targeted cancer treatment. Each vial contains 50mg of Brentuximab Vedotin as a lyophilized powder, reconstituted and given through intravenous infusion over 30 minutes. It specifically targets CD30-positive cancer cells, delivering cancer-killing medicine directly into them while minimizing harm to healthy cells.

Indications

Adcitris is used for the treatment of:

• Relapsed or refractory Hodgkin lymphoma, especially after stem cell transplant or failed chemotherapy.

• Systemic anaplastic large cell lymphoma (sALCL) in patients not responding to standard therapy.

• First-line treatment of advanced Hodgkin lymphoma (Stage III/IV), usually in combination with chemotherapy.

• Certain CD30-positive T-cell lymphomas, such as primary cutaneous ALCL and peripheral T-cell lymphoma.

Dosage & Administration

• Standard Dose (Monotherapy): 1.8mg/kg (up to 180mg maximum) once every 3 weeks.

• Combination Therapy (Advanced Hodgkin Lymphoma): 1.2mg/kg (up to 120mg maximum) every 2 weeks.

• Administered only under medical supervision as an intravenous infusion.

• Dose adjustments may be required based on liver, kidney function, or patient tolerance.

Warnings & Precautions

• Peripheral Neuropathy: Tingling, numbness, or weakness may occur with repeated doses.

• Infusion Reactions: Some patients may develop allergic or severe reactions during infusion.

• Hematologic Effects: Low white blood cells, anemia, or thrombocytopenia may occur; regular blood tests are required.

• Infections: Increased risk of bacterial, viral, or fungal infections.

• Liver & Lung Toxicity: Monitor for breathing difficulty or abnormal liver function tests.

• Severe Skin Reactions: Rare but possible (Stevens-Johnson syndrome, TEN).

• Pregnancy & Breastfeeding: Not recommended during pregnancy or while nursing.

Common Side Effects

• Fatigue, fever, nausea, diarrhea, vomiting.

• Skin rash or itching.

• Cough, shortness of breath.

• Decreased appetite, weight loss.

• Neuropathy (numbness, tingling in hands/feet).

• Low blood counts (neutropenia, anemia, thrombocytopenia).

Storage Instructions

• Store vials in a refrigerator (2–8°C).

• Protect from direct sunlight and moisture.

• Reconstituted solution should be used immediately or within the timeframe recommended by the manufacturer.

Summary Table

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