Nintib 150mg Capsule (Nintedanib) 

Nintib 150mg Capsule contains Nintedanib 150mg, an antifibrotic medicine manufactured by Cipla Limited. It belongs to a class of medicines known as tyrosine kinase inhibitors and is prescribed for adults with certain progressive fibrosing lung diseases.

Nintedanib works by blocking specific signalling pathways involved in the development of fibrosis (scarring) in lung tissue. By inhibiting these pathways, it helps slow the progression of lung scarring and the decline in lung function. It does not reverse existing lung damage or cure pulmonary fibrosis, but it may help patients preserve their remaining lung function for longer.

Nintib 150mg is a prescription-only medicine and should only be used under the supervision of a qualified pulmonologist or specialist.

Product Information

• Brand Name: Nintib 150
• Generic Name: Nintedanib
• Strength: 150mg
• Dosage Form: Soft Gelatin Capsule
• Manufacturer: Cipla Limited
• Pack Size: 10 Capsules
• Therapeutic Category: Antifibrotic Agent / Tyrosine Kinase Inhibitor
• Availability: Contact MedicineWalyDost.com for availability and ordering information.

Uses and Benefits of Nintib 150mg Capsule

Nintedanib is prescribed for specific chronic lung conditions associated with progressive fibrosis. Its main approved uses include:

1. Idiopathic Pulmonary Fibrosis (IPF)

Idiopathic pulmonary fibrosis is a chronic lung disease in which lung tissue gradually becomes scarred and stiff. This can make breathing increasingly difficult and reduce the lungs’ ability to transfer oxygen into the bloodstream. Nintedanib helps slow the decline in lung function in adults with IPF.

2. Progressive Fibrosing Interstitial Lung Disease (ILD)

Certain interstitial lung diseases cause persistent inflammation and scarring of lung tissue. In patients whose disease continues to progress despite appropriate management, Nintedanib may help slow the deterioration of lung function.

3. Systemic Sclerosis-Associated Interstitial Lung Disease (SSc-ILD)

Systemic sclerosis, also known as scleroderma, is an autoimmune condition that can affect multiple organs, including the lungs. When it causes interstitial lung disease, Nintedanib may help slow the rate of decline in pulmonary function.

The suitability of Nintedanib depends on the patient’s diagnosis, disease progression, medical history, and specialist assessment.

How Does Nintedanib Work?

Nintedanib is a tyrosine kinase inhibitor that targets several receptors involved in pathways associated with fibrosis. These include platelet-derived growth factor receptors (PDGFR), fibroblast growth factor receptors (FGFR), and vascular endothelial growth factor receptors (VEGFR).

These signalling pathways contribute to processes involved in the growth and activity of cells responsible for producing fibrous tissue. By inhibiting these pathways, Nintedanib helps reduce the processes that contribute to progressive scarring.

The treatment aims to slow further deterioration rather than remove existing scar tissue. Patients should continue their prescribed treatment and attend regular medical follow-ups.

Recommended Dosage and Administration

The commonly recommended adult dosage for Nintedanib in approved pulmonary fibrosis indications is 150mg twice daily, approximately 12 hours apart, taken with food.

However, this is general prescribing information, not an individual treatment recommendation. The appropriate dose must be determined by the treating specialist.

Important administration instructions:

• Take the capsule with food.
• Swallow the capsule whole with water.
• Do not chew, crush, open, or break the capsule.
• Try to take doses at consistent times each day.
• If a dose is missed, follow your doctor’s instructions rather than taking an extra dose.
• Do not increase, reduce, or discontinue the dose without medical advice.

Patients with liver impairment or significant adverse reactions may require a dose adjustment or temporary treatment interruption under medical supervision.

Possible Side Effects

Like other prescription medicines, Nintib 150mg may cause side effects. Their severity and frequency can vary between individuals.

Commonly reported side effects include:

• Diarrhoea
• Nausea and vomiting
• Abdominal pain or discomfort
• Reduced appetite
• Weight loss
• Headache
• Increased liver enzyme levels
• Fatigue
• High blood pressure

Some side effects may require medical assessment, dose modification, or temporary interruption of treatment.

Serious warning signs

Contact a healthcare professional promptly if you experience unusual bleeding, severe or persistent diarrhoea, yellowing of the skin or eyes, dark urine, severe abdominal pain, chest pain, or symptoms suggesting liver injury or a blood clot. Seek emergency care for severe or sudden symptoms.

Precautions and Safety Information

Before starting Nintib 150mg, inform your doctor about your complete medical history and all medicines you are currently taking.

Liver health: Nintedanib can increase liver enzymes and may cause drug-induced liver injury. Liver function tests are recommended before treatment and periodically during therapy.

Bleeding risk: Nintedanib may increase the risk of bleeding. Patients with bleeding disorders or those taking anticoagulants and other medicines that affect blood clotting require careful assessment.

Heart and blood vessel conditions: Inform your doctor if you have a history of heart disease, blood clots, or cardiovascular problems.

Gastrointestinal problems: Severe abdominal pain, persistent diarrhoea, or symptoms of gastrointestinal perforation require urgent medical assessment.

Surgery and wound healing: Inform your healthcare team if you have recently undergone surgery or are planning a surgical procedure, because Nintedanib may affect wound healing.

Pregnancy: Nintedanib may harm an unborn baby. Women who can become pregnant should discuss pregnancy testing and effective contraception with their doctor before and during treatment, as advised.

Breastfeeding: Breastfeeding is not recommended during Nintedanib treatment.

Smoking: Inform your doctor if you smoke, as smoking can affect Nintedanib exposure and treatment response.

Contraindications and Drug Interactions

Nintedanib should not be used without a specialist’s assessment of its benefits and risks.

Patients with moderate or severe liver impairment are generally not recommended to receive Nintedanib. Patients with mild liver impairment may require a lower prescribed dose.

Certain medicines can affect Nintedanib levels in the body. Drugs that inhibit or induce P-glycoprotein (P-gp) and CYP3A4 may alter its exposure. Blood thinners and other medicines that increase bleeding risk also require particular attention.

Always disclose prescription medicines, non-prescription products, vitamins, and herbal supplements to your doctor or pharmacist before starting treatment.

Storage Instructions

• Store according to the manufacturer’s instructions on the packaging.
• Keep the capsules in their original packaging.
• Protect the medicine from excessive heat and moisture.
• Keep out of reach of children.
• Do not use expired or damaged capsules.

Nintib 150mg Capsule Price in Pakistan

The price of Nintib 150mg Capsule in Pakistan may vary depending on availability, import conditions, supplier pricing, and stock status.

For the latest price and availability of Nintib 150mg (Nintedanib), contact MedicineWalyDost.com. Our team can assist with availability enquiries and ordering information for specialty and imported medicines.

Frequently Asked Questions (FAQs)

1. What is Nintib 150mg Capsule used for?

Nintib 150mg contains Nintedanib and is prescribed for adults with idiopathic pulmonary fibrosis, progressive fibrosing interstitial lung diseases, and systemic sclerosis-associated interstitial lung disease.

2. What is the generic name of Nintib 150?

The generic name is Nintedanib. Each capsule contains 150mg of Nintedanib.

3. Who manufactures Nintib 150mg Capsule?

Nintib 150mg is manufactured by Cipla Limited.

4. How many capsules are included in one pack?

The product pack shown is a pack of 10 capsules. Always check the packaging and product details before ordering.

5. How should Nintib 150mg be taken?

The commonly recommended adult dose is 150mg twice daily, approximately 12 hours apart, with food. The treating specialist must confirm the appropriate dose for each patient.

6. Does Nintedanib cure pulmonary fibrosis?

No. Nintedanib is not a cure for pulmonary fibrosis and does not reverse existing lung scarring. It helps slow the decline in lung function in patients with certain progressive fibrosing lung diseases.

7. Can Nintib 150mg cause diarrhoea?

Yes. Diarrhoea is one of the commonly reported side effects. Persistent or severe diarrhoea should be discussed with a healthcare professional.

8. Do I need a prescription to purchase Nintib 150mg?

Yes. Nintedanib is a prescription medicine and should be used only under specialist supervision.

9. Is Nintib 150mg available in Pakistan?

For current availability, pricing, and ordering assistance, contact MedicineWalyDost.com.

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Important Medical Disclaimer: This product information is provided for general educational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Nintib 150mg is a prescription medicine. Use it only as directed by your specialist.