Primidone 250mg Tablet – Epilepsy & Seizure Control Medicine in Pakistan

Primidone 250mg Tablet is a prescription anti-epileptic medication used to treat and manage various types of seizures, including generalized tonic-clonic (grand mal) and partial seizures. It belongs to the class of drugs known as barbiturate-related anticonvulsants and is trusted by neurologists in Pakistan for effective and long-term seizure control.

Primidone works by calming abnormal nerve signals in the brain and is often used alone or in combination with other seizure medications to control epilepsy symptoms.

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What is Primidone 250mg Used For?

Primidone is prescribed for:

• Epilepsy (Generalized and Focal Seizures)

• Grand Mal (Tonic-Clonic) Seizures

• Complex Partial Seizures

• Myoclonic Epilepsy (in some cases)

• Adjunct therapy with other antiepileptics when monotherapy isn’t effective

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How Does Primidone Work?

Primidone is metabolized in the body into two active substances:

• Phenobarbital

• PEMA (phenylethylmalonamide)

These compounds work by:

• Suppressing abnormal electrical activity in the brain

• Stabilizing the nervous system

• Preventing seizure attacks by decreasing the excitability of nerve cells

This dual-action mechanism gives it a longer-lasting and broader seizure protection.

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Dosage Information

Primidone should be taken only as prescribed by your doctor. The dosage varies based on age, body weight, and severity of the condition.

Typical Adult Dosage:

• Start with 100–125mg at bedtime

• Gradually increase to 250mg 3 to 4 times daily as tolerated

• Maintenance dose: Usually between 500mg to 1500mg/day, divided

Children: Dosage is weight-based and prescribed by a pediatric neurologist.

💊 Swallow the tablet whole with water. Do not crush or chew.

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Side Effects of Primidone 250mg Tablet

Most people tolerate Primidone well, but some may experience side effects, especially during the initial days of treatment or dose adjustment.

Common Side Effects:

• Drowsiness or sleepiness

• Dizziness

• Nausea or vomiting

• Loss of coordination

• Blurred vision

• Fatigue or weakness

Serious Side Effects:

• Mood changes, depression, or suicidal thoughts

• Skin rash, itching, or allergic reactions

• Blood disorders (rare)

• Respiratory depression (rare but serious)

Seek immediate medical help if you notice severe allergic symptoms, confusion, or unusual bleeding.

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Warnings & Precautions

• Do not stop taking the medicine suddenly. Taper the dose slowly under medical supervision.

• Avoid alcohol, which may increase sedation.

• Not recommended during pregnancy or breastfeeding without medical advice.

• Regular blood tests, liver, and kidney function monitoring may be required for long-term users.

• Caution in elderly patients due to increased sedation risk.

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FAQs – Frequently Asked Questions

Q: What is the function of Primidone 250mg?

It prevents seizures by reducing overactivity in the brain’s nerves.

Q: Is Primidone the same as Phenobarbital?

No, but Primidone breaks down into Phenobarbital, one of its active metabolites. Both work to prevent seizures.

Q: Can I take Primidone with other epilepsy medications?

Yes, but only under medical supervision, as dose adjustments may be needed.

Q: How fast does Primidone work?

Initial effects may begin in a few hours, but full seizure control may take days to weeks depending on the patient.

Q: Can Primidone be used for children?

Yes, but only under strict pediatric supervision. Dosage depends on age and weight.

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