Xtandi 40mg Capsule (Enzalutamide) – Complete Product Description

Xtandi 40mg Capsule (Enzalutamide) is a prescription medicine manufactured by Astellas and used in the treatment of certain types of advanced prostate cancer. It contains enzalutamide, an androgen receptor inhibitor that works by blocking the effects of male hormones called androgens, which can stimulate prostate cancer cells to grow.

Enzalutamide is an important oral hormone therapy used for patients with advanced prostate cancer, including certain cases of metastatic and non-metastatic castration-resistant prostate cancer and metastatic hormone-sensitive prostate cancer, depending on the applicable treatment indication.

The product listed here is Xtandi 40mg Capsule, manufactured by Astellas, with a pack size of 112 capsules. Xtandi is intended for oral use and should be taken according to the treatment plan prescribed by an experienced oncologist or urologist.

Xtandi 40mg Capsule – Product Information

Brand Name: Xtandi
Active Ingredient: Enzalutamide
Strength: 40mg
Dosage Form: Capsule
Route of Administration: Oral
Manufacturer: Astellas
Pack Size: 112 Capsules
Drug Class: Androgen receptor inhibitor
Therapeutic Class: Antineoplastic / Hormonal cancer therapy
Prescription Status: Prescription medicine

What Is Xtandi 40mg Capsule Used For?

Xtandi contains enzalutamide and is used for the treatment of selected patients with prostate cancer.

Depending on the approved indication and patient’s clinical condition, enzalutamide may be prescribed for:

• Metastatic castration-resistant prostate cancer (mCRPC)
• Non-metastatic castration-resistant prostate cancer (nmCRPC)
• Metastatic hormone-sensitive prostate cancer (mHSPC)

The exact indication depends on disease stage, previous treatment, hormone sensitivity, metastatic status and the treatment strategy selected by the specialist.

Xtandi for Castration-Resistant Prostate Cancer

Some prostate cancers continue to grow despite very low testosterone levels achieved through androgen-deprivation therapy. This condition is known as castration-resistant prostate cancer (CRPC).

Xtandi can block androgen-receptor signaling even when testosterone levels are already reduced, helping slow the progression of prostate cancer in appropriately selected patients.

Xtandi for Metastatic Prostate Cancer

In selected patients with metastatic prostate cancer, enzalutamide may be used as part of systemic treatment.

Metastatic prostate cancer means that cancer has spread beyond the prostate to other parts of the body. Xtandi can help suppress androgen-receptor signaling and may delay disease progression.

How Does Xtandi (Enzalutamide) Work?

Xtandi contains enzalutamide, a potent androgen receptor inhibitor.

Prostate cancer cells commonly depend on androgen receptor signaling for growth and survival. Androgens such as testosterone and dihydrotestosterone activate the androgen receptor, which can stimulate prostate cancer cells.

Enzalutamide works by interfering with androgen receptor signaling through several mechanisms. It:

• Inhibits androgen binding to the androgen receptor
• Prevents androgen receptor movement into the cell nucleus
• Reduces androgen receptor interaction with DNA

By blocking these signals, enzalutamide can reduce the stimulation that prostate cancer cells receive from male hormones.

Xtandi is therefore a targeted hormonal therapy rather than traditional cytotoxic chemotherapy.

Xtandi 40mg Dose and Administration

The commonly recommended adult dose of enzalutamide is 160mg once daily.

With 40mg capsules, this may correspond to four 40mg capsules once daily, depending on the prescribed formulation and treatment plan.

Xtandi can generally be taken with or without food. Capsules should be swallowed whole with water and should not be chewed, opened or dissolved.

Patients should take Xtandi at approximately the same time each day.

The treating physician may adjust or temporarily interrupt treatment depending on adverse effects, other medicines, liver function and the patient’s overall clinical condition.

Do not change the dose or stop Xtandi without consulting your doctor.

Missed Dose of Xtandi

If a dose of Xtandi is missed, the patient should follow the instructions provided by the treating healthcare professional or official prescribing information.

Do not take extra capsules to compensate for a missed dose unless specifically instructed by your healthcare provider.

Common Side Effects of Xtandi 40mg

Like all medicines, Xtandi can cause side effects. Commonly reported adverse effects may include:

• Fatigue
• Weakness
• Hot flushes
• Headache
• Dizziness
• High blood pressure
• Falls
• Fractures
• Back pain
• Joint pain
• Muscle pain
• Decreased appetite
• Diarrhea
• Nausea
• Weight loss

Patients receiving Xtandi should inform their healthcare provider if side effects are persistent, severe or interfere with daily activities.

Serious Side Effects of Xtandi

Seizures

Enzalutamide may increase the risk of seizures, although this is uncommon.

Patients with a history of seizures or conditions that increase seizure risk should inform their doctor before starting treatment.

Seek urgent medical attention if a seizure occurs.

Posterior Reversible Encephalopathy Syndrome

Rare cases of posterior reversible encephalopathy syndrome (PRES) have been reported.

Possible symptoms can include:

• Seizures
• Severe headache
• Confusion
• Vision changes
• Reduced awareness

Immediate medical evaluation is required if these symptoms occur.

Falls and Fractures

Xtandi treatment can be associated with an increased risk of falls and fractures, particularly in older patients or those with weakened bones.

Patients should take appropriate precautions and discuss bone health with their healthcare provider.

Heart and Blood Pressure Problems

Enzalutamide may increase blood pressure. Patients with cardiovascular disease or hypertension should inform their healthcare provider before starting treatment.

Regular blood pressure monitoring may be recommended.

Precautions Before Taking Xtandi 40mg

Tell your doctor before taking Xtandi if you have:

• A history of seizures
• Brain injury
• Stroke
• Brain tumor or other neurological conditions
• Cardiovascular disease
• High blood pressure
• Liver problems
• A history of falls or fractures
• Osteoporosis or other bone-health problems

Tell your healthcare professional about all medicines, supplements and herbal products you are taking.

Xtandi Drug Interactions

Enzalutamide can affect the activity of several drug-metabolizing enzymes and transport proteins. As a result, it can interact with many medicines.

Your doctor should review your medication list before starting Xtandi.

Particular care may be needed with medicines that have a narrow therapeutic range or depend heavily on certain liver enzymes for their metabolism.

Do not start a new prescription, over-the-counter medicine or supplement without discussing it with your healthcare provider.

Xtandi and Androgen-Deprivation Therapy

Depending on the indication, Xtandi may be administered together with androgen-deprivation therapy (ADT).

Patients whose prostate cancer has not undergone surgical removal of the testes generally continue appropriate ADT during enzalutamide treatment.

The exact treatment combination should be determined by the treating oncologist or urologist.

Xtandi During Pregnancy

Xtandi is not intended for use in women.

Enzalutamide may cause fetal harm if exposure occurs during pregnancy. Men receiving Xtandi who have partners who can become pregnant should follow appropriate contraceptive precautions as recommended by their healthcare provider.

Because enzalutamide may affect sperm production and reproductive function, patients should discuss fertility and family-planning considerations with their physician.

Xtandi and Breastfeeding

Xtandi is not indicated for women and should not be used during breastfeeding.

Women who are pregnant, breastfeeding or planning pregnancy should not handle Xtandi capsules unless specifically instructed and appropriate precautions are taken.

Xtandi 40mg Storage

Store Xtandi according to the manufacturer’s recommended storage conditions.

Keep the capsules in their original packaging and protect them from excessive heat and moisture.

Keep Xtandi out of the reach of children.

Do not use the medicine after the expiry date printed on the package.

Xtandi 40mg Capsule Price in Pakistan

The Xtandi 40mg Capsule price in Pakistan may vary depending on availability, supplier, import costs, exchange rates and prevailing market conditions.

For the latest Xtandi 40mg price in Pakistan, customers can contact MedicineWalyDost.com to check current availability and pricing.

As Xtandi is a specialized prescription oncology medicine, prices can change based on market availability. Confirm the current price before placing an order.

Why Choose Xtandi 40mg Capsule?

Xtandi contains enzalutamide, an established androgen receptor inhibitor used in the management of selected forms of advanced prostate cancer.

Its targeted mechanism blocks androgen receptor signaling, an important pathway involved in prostate cancer growth and progression.

The Astellas Xtandi 40mg Capsule presentation is supplied in a pack size of 112 capsules, providing a convenient oral formulation for patients following a prescribed enzalutamide treatment regimen.

Frequently Asked Questions About Xtandi 40mg

What is Xtandi 40mg Capsule?

Xtandi 40mg Capsule is a prescription prostate cancer medicine containing enzalutamide, an androgen receptor inhibitor.

What is the generic name of Xtandi?

The generic name is enzalutamide.

Who manufactures Xtandi 40mg?

The manufacturer of the product listed here is Astellas.

What is the pack size of Xtandi 40mg?

The pack size is 112 capsules.

What is Xtandi used for?

Xtandi is used for selected patients with advanced prostate cancer, including certain forms of metastatic and non-metastatic castration-resistant prostate cancer and metastatic hormone-sensitive prostate cancer.

What is the usual Xtandi dose?

The commonly recommended adult dose is 160mg once daily, equivalent to four 40mg capsules when the 40mg capsule formulation is prescribed. The treating physician determines the appropriate regimen.

Can Xtandi be taken with food?

Yes. Enzalutamide can generally be taken with or without food. Capsules should be swallowed whole.

Is Xtandi chemotherapy?

No. Xtandi is a hormonal targeted therapy known as an androgen receptor inhibitor. It works differently from conventional chemotherapy.

Can Xtandi be taken with hormone therapy?

Yes. Depending on the patient’s treatment setting, Xtandi may be used together with androgen-deprivation therapy.

Does Xtandi cause seizures?

Seizures are an uncommon but serious potential adverse effect of enzalutamide. Patients with a history of seizures or other risk factors should discuss them with their doctor before treatment.

Can Xtandi be purchased without a prescription?

Xtandi is a specialized prescription cancer medicine and should only be used under the supervision of a qualified oncologist or urologist.

Order Xtandi 40mg Capsules in Pakistan

Looking for Xtandi 40mg Capsules (Enzalutamide) by Astellas in Pakistan?

MedicineWalyDost.com provides access to specialized prescription medicines and oncology products. Contact us to check the latest Xtandi 40mg price, availability and ordering information.

Before ordering, confirm the brand, strength, active ingredient, manufacturer, pack size and prescription requirements with your doctor or pharmacist.

Order Xtandi 40mg Capsules from MedicineWalyDost.com and contact us today for current availability and pricing.

Important Medical Disclaimer

Xtandi 40mg Capsule is a prescription oncology medicine. This product description is intended for educational and e-commerce purposes only and does not replace professional medical advice. Enzalutamide can cause serious adverse effects and has important drug interactions. It should be used under the supervision of a qualified healthcare professional. Do not start, stop or change the dose of Xtandi without consulting your treating specialist.